Consulta: creatorFacets:"Muñoz,María José"
Registros recuperados: 2
Data/hora: 19/05/2024 04:07:40

Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate
Provedor de dados: Genetics and Molecular Biology
Autores: Paz-y-Miño,César; Sánchez,María Eugenia; Arévalo,Melissa; Muñoz,María José; Witte,Tania; De-la-Carrera,Gabriela Oleas; Leone,Paola E.
We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in the northern part of Ecuador. A total of 24 exposed and 21 unexposed control individuals were investigated using the comet assay. The results showed a higher degree of DNA damage in the exposed group (comet length = 35.5 µm) compared to the control group (comet length = 25.94 µm). These results suggest that in the formulation used during aerial spraying glyphosate had a genotoxic effect on the exposed individuals.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Comet assay; DNA damage; Ecuador; Genotoxicity; Glyphosate.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300026

Relationship of an hRAD54 gene polymorphism (2290 C/T) in an Ecuadorian population with chronic myelogenous leukemia
Provedor de dados: Genetics and Molecular Biology
Autores: Paz-y-Miño,César; López-Cortés,Andrés; Muñoz,María José; Castro,Bernardo; Cabrera,Alejandro; Sánchez,María Eugenia.
The hRAD54 gene is a key member of the RAD52 epistasis group involved in repair of double-strand breaks (DSB) by homologous recombination (HR). Thus, alterations of the normal function of these genes could generate genetic instability, shifting the normal process of the cell cycle, leading the cells to develop into cancer. In this work we analyzed exon 18 of the hRAD54 gene, which has been previously reported by our group to carry a silent polymorphism, 2290 C/T (Ala730Ala), associated to meningiomas. We performed a PCR-SSCP method to detect the polymorphism in 239 samples including leukemia and normal control population. The results revealed that the 2290 C/T polymorphism has frequencies of 0.1 for the leukemia and 0.1 for the control group. These...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cancer; Leukemia; CML; ALL; HRAD54; 2290 C/T polymorphism.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400009